LB918 The dark side of hydroquinone for skin lightening: 3-fold increased risk of skin cancer - a cohort study

Purpose: For years, concern has persisted that hydroquinone exposure in humans may be associated with increased risk of cancer but proving this been elusive. The purpose study is to use the TriNetX database quantify humans. Methods: We used platform create 2 cohorts patients, both without any prior diagnosis skin cancer. One cohort had received which was determined by medication code 5509 system, while other prohibited from having such exposure. They were then evaluated for development melanoma and non-melanoma cancers via ICD-10 codes C43.x C44.x, respectively. Type Study: Cohort: Results: Hydroquinone a relative 3 (95% CI (1.704,5.281), p<0.0001), 3.6 (2.815,4.561), 3.4 all reported combined (2.731,4.268), p<0.0001). Conclusion: Our shows increases more than 3-fold. This information will useful informed consent process patients who desire treatment encourage mitigation avoidance sun compliance sunscreen.